Hidenobu Murafuji Selected Research

1- cyclohexyl- N- (6- (4- hydroxy- 1- piperidinyl)- 3- pyridinyl)- 3- methyl- 1H- thieno(2,3- c)pyrazole- 5- carboxamide

5/2010	Phosphodiesterase 7A inhibitor ASB16165 impairs proliferation of keratinocytes in vitro and in vivo.
6/2009	ASB16165, a phosphodiesterase 7A inhibitor, reduces cutaneous TNF-alpha level and ameliorates skin edema in phorbol ester 12-O-tetradecanoylphorbol-13-acetate-induced skin inflammation model in mice.

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Hidenobu Murafuji Research Topics

Disease

2	Inflammation (Inflammations) 05/2010 - 06/2009
1	Psoriasis (Pustulosis Palmaris et Plantaris) 05/2010
1	Hyperplasia 05/2010
1	Hepatitis 10/2009
1	Dermatitis 06/2009
1	Edema (Dropsy) 06/2009

Drug/Important Bio-Agent (IBA)

3	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 05/2010 - 06/2009
2	1- cyclohexyl- N- (6- (4- hydroxy- 1- piperidinyl)- 3- pyridinyl)- 3- methyl- 1H- thieno(2,3- c)pyrazole- 5- carboxamideIBA 05/2010 - 06/2009
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2009 - 06/2009
1	CytokinesIBA 10/2009
1	1- cyclohexyl- N- (3- fluoro- 4- (4- methyl- 1- piperazinyl)phenyl)- 3- methyl- 1H- thieno(2,3- c)pyrazole- 5- carboxamideIBA 10/2009
1	Concanavalin AIBA 10/2009
1	Pharmaceutical PreparationsIBA 10/2009
1	Interleukin-4 (Interleukin 4)IBA 10/2009
1	alpha-galactosylceramideIBA 10/2009
1	Phorbol EstersIBA 06/2009